Drug Delivery by Tattooing to Treat Cutaneous Leishmaniasis
نویسندگان
چکیده
منابع مشابه
Drug Delivery by Tattooing to Treat Cutaneous Leishmaniasis
This study establishes a proof-of-concept that a tattoo device can target intra-dermal drug delivery against cutaneous leishmaniasis (CL). The selected drug is oleylphosphocholine (OlPC) formulated as liposomes, particles known to be prone to macrophage ingestion. We first show that treatment of cultured Leishmania-infected macrophages with OlPC-liposomes results in a direct dose-dependent kill...
متن کاملCutaneous Complications Related to Tattooing
Decorative permanent tattooing involves the introduction of exogenous pigments and/or dyes into the dermis to produce a permanent design (1). For the past 20 years tattooing has gained tremendous popularity, especially among young people (2, 3). However, the frequency of cutaneous complications related to tattooing is unknown. Kazandjieva & Tsankov (4) estimated the prevalence of complications ...
متن کاملTargeted drug delivery to treat pain and cerebral hypoxia.
Limited drug penetration is an obstacle that is often encountered in treatment of central nervous system (CNS) diseases including pain and cerebral hypoxia. Over the past several years, biochemical characteristics of the brain (i.e., tight junction protein complexes at brain barrier sites, expression of influx and efflux transporters) have been shown to be directly involved in determining CNS p...
متن کاملLow efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil.
An open trial to evaluate the azithromycin efficacy in cutaneous leishmaniasis patients was carried out in Manaus (AM), where Leishmania (Viannia) guyanensis is the main etiologic agent. Forty-one patients with skin lesions of less than 12 weeks duration, without specific treatment for the last three months and a positive imprint to Leishmania sp. were included. From these, 31 (75.6%) were male...
متن کاملFailure of both azithromycin and antimony to treat cutaneous leishmaniasis in Manaus, AM, Brazil.
A non-randomized controlled clinical trial was carried out in order to evaluate both azithromycin and antimony efficacy in cutaneous leishmaniasis in Manaus, AM, Brazil. Forty nine patients from both genders, aged 14 to 70, with cutaneous ulcers for less than three months and a positive imprint for Leishmania spp. amastigotes were recruited into two groups. Group I (26 patients) received a dail...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2014
ISSN: 2045-2322
DOI: 10.1038/srep04156